Adaptive designs for subpopulation analysis optimizing utility functions
نویسندگان
چکیده
منابع مشابه
Adaptive designs for subpopulation analysis optimizing utility functions
If the response to treatment depends on genetic biomarkers, it is important to identify predictive biomarkers that define (sub-)populations where the treatment has a positive benefit risk balance. One approach to determine relevant subpopulations are subgroup analyses where the treatment effect is estimated in biomarker positive and biomarker negative groups. Subgroup analyses are challenging b...
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ژورنال
عنوان ژورنال: Biometrical Journal
سال: 2014
ISSN: 0323-3847,1521-4036
DOI: 10.1002/bimj.201300257